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Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial

Clinical trials and meta-analyses indicated that concurrent administration of GnRH agonists during chemotherapy markedly reduced the incidence of POF and enhanced the likelihood of restarting menstruation and ovarian function following treatment (Blumenfeld and Wolff 2008

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Human clinical data in this area remain more limited but are broadly consistent with the mechanistic findings observed in animal research